Our main objective is to study nutrition in the prevention and treatment of cardiovascular disease and related metabolic disorders. The working hypothesis is that a Paleolithic diet (the Paleolithic is the time period 2,000,000-10,000 years BP), basically meat, fish, vegetables, fruit and nuts, has benefits even compared with prudent diets based on whole-grain cereals and low-fat milk.
The basic notions are that
1) foods are appropriate for any given species if they were regularly consumed during most of its prior evolution;
2) plants protect themselves with bioactive substances directly aimed at animals, substances which may have untoward effects on long-term human health.
Selected articles
1. Lindeberg, S, Jönsson, T, Granfeldt, Y, Borgstrand, E, Soffman, J, Sjöström, K, and Ahrén, B. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia, 2007; In press: http://www.springerlink.com/content/h7628r66r0552222
2. Lindeberg, S. Modern human phsyiology with respect to evolutionary adaptations that relate to diet in the past, in The Evolution of Hominid Diets: integrating approaches to the study of Palaeolithic subsistence, M.P. Richards and J.J. Hublin, Editors. in press, Elsevier.
3. Frostegard, J, Tao, W, Georgiades, A, Rastam, L, Lindblad, U, and Lindeberg, S. Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea. Nutr Metab (Lond), 2007; 4: 7 >>Free full text>>
4. Jönsson, T, Ahren, B, Pacini, G, Sundler, F, Wierup, N, Steen, S, Sjoberg, T, Ugander, M, Frostegard, J, Goransson, L, and Lindeberg, S. A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutr Metab (Lond), 2006; 3: 39 >>Free full text>>
6. Jönsson, T, Olsson, S, Ahrén, B, Bøg-Hansen, TC, Dole, A, and Lindeberg, S. Agrarian diet and dieases of affluence - Do evolutionary novel dietary lectins cause leptin resistance? BMC Endocrine Dis, 2005; 5: doi:10.1186/1472-6823-5-10 >>Free full text>>
7. Cordain, L, Eaton, SB, Sebastian, A, Mann, N, Lindeberg, S, Watkins, BA, O'Keefe, JH, and Brand-Miller, J. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr, 2005; 81: 341-54 >>Free full text>>
8. Lindeberg, S, Cordain, L, and Eaton, SB. Biological and clinical potential of a palaeolithic diet. J Nutr Environ Med, 2003; 13: 1-12
9. Lindeberg, S. Stroke in Papua New Guinea. Lancet Neurol, 2003; 2: 273
10. Cordain, L, Eaton, SB, Brand Miller, J, Lindeberg, S, and Jensen, C. An evolutionary analysis of the aetiology and pathogenesis of juvenile-onset myopia. Acta Ophthalmol Scand, 2002; 80: 125-35 >>Free full text>>
11. Eaton, SB, Cordain, L, and Lindeberg, S. Evolutionary health promotion: a consideration of common counterarguments. Prev Med, 2002; 34: 119-123
12. Eaton, SB, Strassman, BI, Nesse, RM, Neel, JV, Ewald, PW, Williams, GC, Weder, AB, Eaton, SB, 3rd, Lindeberg, S, Konner, MJ, Mysterud, I, and Cordain, L. Evolutionary health promotion. Prev Med, 2002; 34: 109-118
13. Cordain, L, Lindeberg, S, Hurtado, M, Hill, K, Eaton, SB, and Brand Miller, J. Acne vulgaris: a disease of civilization. Arch Dermatol, 2002; 138: 1584-90. >>Free full text>>
14. Lindeberg, S, Soderberg, S, Ahren, B, and Olsson, T. Large differences in serum leptin levels between nonwesternized and westernized populations: the Kitava study. J Intern Med, 2001; 249: 553-8. >>Free full text>>
15. Lindeberg, S, Eliasson, M, Lindahl, B, and Ahrén, B. Low serum insulin in traditional Pacific Islanders--the Kitava Study. Metabolism, 1999; 48: 1216-1219
16. Lindeberg, S, Berntorp, E, Nilsson-Ehle, P, Terent, A, and Vessby, B. Age relations of cardiovascular risk factors in a traditional Melanesian society: the Kitava Study. Am J Clin Nutr, 1997; 66: 845-52 >>Free full text>>
17. Lindeberg, S, Berntorp, E, Carlsson, R, Eliasson, M, and Marckmann, P. Haemostatic variables in Pacific Islanders apparently free from stroke and ischaemic heart disease. Thromb Haemost, 1997; 77: 94-8
18. Lindeberg, S. Apparent absence of cerebrocardiovascular disease in Melanesians. Risk factors and nutritional considerations - the Kitava Study. 1994, University of Lund.
19. Lindeberg, S, Nilsson-Ehle, P, Terént, A, Vessby, B, and Scherstén, B. Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease — the Kitava study. J Intern Med, 1994; 236: 331-340
20. Lindeberg, S and Lundh, B. Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: a clinical study in Kitava. J Intern Med, 1993; 233: 269-275
Our research
The Kitava Study
No signs of cardiovascular disease in a non-western population. Excellent risk factor levels. >>read more>>
Paleolithic diet in humans
Improved glucose tolerance after 3 months in the first controlled human trial. >>read more>>
Paleolithic diet in pigs
Improved insulin sensitivity, CRP and blood pressure in the first animal experiment. >>read more>>
Literature surveys
Accumulated evidence favors an evolutionary perspective. >>read more>>
